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Teduglutide is a medication used to treat short bowel syndrome (SBS) in patients who require parenteral support (intravenous nutrition or fluids). It is a glucagon-like peptide-2 (GLP-2) analog that helps the intestines absorb more fluids and nutrients.
The glucagon‐like peptide 2 analogue teduglutide is an effective drug for the treatment of short bowel syndrome patients with intestinal failure (SBS‐IF). This intestinotrophic peptide improves intestinal capacity for fluid and nutrient absorption through induction of mucosal growth and reduction of gastrointestinal motility. Clinical trials demonstrated the efficacy of teduglutide in reducing the need for parenteral support (PS).
A retrospective analysis was performed using data of patients experiencing nonmalignant SBS‐IF. They were treated with teduglutide in a multidisciplinary SBS‐IF program at a single university medical center between June 2016 and June 2020.
Integrating SBS‐IF patients treated with teduglutide in a proactive and tight‐meshed patient care program significantly improves the clinical outcome, leading to an increased proportion of patients reaching enteral autonomy.
Teduglutide is highly effective in treating patients with SBS‐IF. In addition to the results of previous studies that demonstrated significant reductions of the PS, this study provides evidence that the integration of this heterogeneous patient population into a multiprofessional team spearheaded by a dietitian enables enteral autonomy under teduglutide therapy in nearly all treated patients.
Enteral autonomy, as the final goal of a treat‐to‐target strategy, seems necessary, as it results not only in a decreased morbidity and mortality but also in improvement of QoL and may reduce the socioeconomic burden.
