Thin
Explore our core clinical-grade peptide catalog produced under strict analytical validation, with individual Certificate of Analysis (CoA), MS verification, and HPLC purity profiles.
Kisspeptins—encoded by the KISS1 gene and acting through the G-protein-coupled receptor GPR54 (KISS1R)—serve as the upstream master regulator of the hypothalamic-pituitary-gonadal (HPG) axis. Precision sourcing requires profound biochemical insight into peptide length, amidation state, and impurity profiles.
Sequence: Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2. The shortest endogenous biologically active cleavage product retaining full nanomolar affinity for KISS1R. Essential for acute gonadotropin pulse induction studies.
54-Amino-Acid Polypeptide: The native prepropeptide processed form. Exhibiting enhanced serum half-life relative to KP-10, KP-54 is extensively leveraged in controlled ovarian stimulation (COS) and clinical oncology research.
Tailored structural derivatives engineered for enhanced metabolic stability, including D-amino acid substitutions, lipidated fatty acid side chains (similar to GLP-1 platforms), and non-natural spacers for extended pharmacokinetics.
Industrial scale-up of kisspeptin peptides demands overcoming classic synthetic hurdles: steric hindrance, C-terminal epimerization, and high solvent consumption. Our Hangzhou technical roadmap transitions legacy batch processes into continuous digitalized manufacturing.
Replacement of hazardous DMF/NMP with sustainable green dipolar aprotic alternatives (such as 2-MeTHF and Cyrene). This mitigates hazardous waste while boosting coupling efficiency for hindered arginine and tryptophan additions by up to 22%.
Eliminating thermal spikes during large-scale trifluoroacetic acid (TFA) resin deprotection. Microreactor continuous flow ensures precise residence times, suppressing tert-butyl re-alkylation on tryptophan and tyrosine rings.
Transitioning from toxic trifluoroacetate salts to pharmaceutical-grade acetate, succinate, or chloride salts using high-capacity automated ion-exchange chromatography, achieving residual TFA levels below 0.1% w/w.
Integration of in-line PAT (Process Analytical Technology) coupled with high-resolution orbitrap mass spectrometry for automated predictive detection of deletion sequences (des-Phe, des-Arg) and diastereomers.
Kisspeptin peptides operate at the crossroads of fertility restoration, hormone-dependent cancer mitigation, and neuroendocrine balance. We engineer batch configurations customized to distinct target regulatory pathways.
Current clinical trials illustrate that Kisspeptin-54 induces a physiologic luteinizing hormone (LH) surge with an exponentially lower risk of Ovarian Hyperstimulation Syndrome (OHSS) compared to recombinant hCG. We deliver injectable-grade, ultra-pure peptide substances designed for clinical investigators developing gentler, safer assisted reproductive technologies.
Originally designated "metastin", KISS1 expression directly suppresses metastasis in melanoma, breast cancer, and endocrine-resistant prostate carcinomas without abolishing tumorigenicity. Our custom-synthesized Kisspeptin receptor agonists enable academic centers and biotechs to probe anti-metastatic signaling cascades without systemic cytotoxicity.
Emerging research proves kisspeptin neurons coordinate nutrient sensing with reproductive viability, interacting closely with GLP-1, leptin, and ghrelin receptor axes. As a major supplier of incretin analogues (Semaglutide, Tirzepatide, Retatrutide), our platform provides dual-targeted research packages for co-metabolic exploration.
Controlled estrus synchronization in high-value equine, bovine, and swine breeding programs increasingly utilizes synthetic kisspeptin derivatives. We supply multi-kilogram commercial lots optimized for stability under variable field storage conditions, ensuring reproducible ovulation stimulation.
Operating from Heda Medicine Valley in Hangzhou, China, our advanced facility bridges the traditional gap between boutique laboratory synthesis and multi-ton commercial peptide manufacturing.
Fully computer-controlled peptide synthesis vessels guarantee precise stoichiometric reagent addition, automated washing phases, and real-time resin agitation monitoring, completely eliminating operator-induced variability across kilograms of product.
We source protected amino acids (Fmoc-Tyr(tBu)-OH, Fmoc-Trp(Boc)-OH, Fmoc-Arg(Pbf)-OH) directly through long-term raw material partnerships within China's domestic supply network, eliminating international tariff bottlenecks and shielding buyers from raw material volatility.
Equipped with 300mm–600mm dynamic axial compression (DAC) reverse-phase HPLC systems, our purification suites separate diastereomers and truncated analogs in single-pass runs, driving unmatched purity with maximum batch yield.
Procuring custom peptide APIs requires an unyielding commitment to international regulatory compliance. We provide complete documentation packages suitable for FDA, EMA, NMPA, and PMDA submissions.
Every batch is accompanied by comprehensive CoA, analytical HPLC chromatograms, HRMS mass confirmation, amino acid analysis (AAA), Karl Fischer water titration, and residual solvent gas chromatography (GC-FID).
Peptide lyophilizates are packaged in amber type-I borosilicate vials, hermetically sealed under nitrogen purge, and shipped via temperature-monitored cold-chain carriers (-20°C / dry ice) with real-time GPS data-logging.
Direct communication across major time zones: dedicated specialist teams for North America & Western Europe, Russia & CIS territories, Asia-Pacific, and the Middle East, ensuring prompt technical answers.
Ready-to-file Type II Drug Master Files (DMFs) for mature generic molecules, combined with open audit policies for qualified pharmaceutical sponsors conducting qualified vendor assessments.
Transparent, volume-tiered pricing frameworks for custom peptide synthesis. Our scale efficiencies empower research institutes and global pharmaceutical developers to forecast development budgets with absolute precision.
| Peptide Name | Sequence / CAS | Purity Grade | Scale Tier | Turnaround Time | Counter-Ion | Pricing / RFQ Status |
|---|---|---|---|---|---|---|
| Kisspeptin-10 | CAS: 374675-21-5 (10-mer) | ≥ 95% (Research) | 100 mg – 1 g | 7 – 10 Days | TFA Salt | From $120 / g |
| Kisspeptin-10 | CAS: 374675-21-5 (10-mer) | ≥ 98% (Preclinical) | 10 g – 100 g | 12 – 15 Days | Acetate / TFA | Tiered Volume RFQ |
| Kisspeptin-10 API | CAS: 374675-21-5 (Amidated) | ≥ 99% (cGMP Grade) | 1 kg – 10 kg+ | Custom Campaign | Pharmaceutical Acetate | Commercial Contract |
| Kisspeptin-54 | Metastin (54-mer Polypeptide) | ≥ 95% (Analytical) | 10 mg – 100 mg | 14 – 18 Days | Lyophilized TFA | From $450 / 10mg |
| Kisspeptin-54 | Native sequence (KISS1R Agonist) | ≥ 98% (In Vivo Ready) | 1 g – 50 g | 20 – 25 Days | Pure Acetate (Low Endotoxin) | Direct Batch Quote |
| Custom Analogs | Lipidated / Cyclic / D-Substituted | ≥ 95% – 99% | Custom (mg to kg) | Design Dependent | Buyer Defined | Full Custom CDMO |
Connect directly with our senior peptide chemists and regional commercial managers. Submit your sequence requirements, required purity, salt choice, and batch targets to receive a binding proposal within 24 hours.
Submit RFQ / Inquire PricelistDetailed technical, regulatory, and purchasing answers compiled by our quality assurance and project management teams.
Discover our comprehensive peptide library spanning metabolic disease agonists, cognitive support neuro-peptides, and aesthetic bio-actives available for worldwide delivery.
