What peptide products does Thinheal supply?

Thinheal supplies generic peptide APIs, therapeutic peptides including GLP-1 and GLP-2 analogues, other gastrointestinal peptides, other therapeutic peptide APIs and cosmetic peptides, plus custom peptide R&D and CDMO manufacturing.

Does Thinheal offer custom peptide synthesis and CDMO services?

Yes. The CDMO business covers project-based contract research and development, contract manufacturing and commercial supply, from route design and process optimization to scale-up of peptide APIs and support toward formulations.

What production capacity does Thinheal have?

Thinheal operates an R&D center and a production base. Total capacity for chemically synthesized peptides has reached a multi-ton level, placing the company among the leading peptide producers in its segment.

Which quality documents can buyers request?

Buyers can request batch-specific Certificates of Analysis with HPLC purity and mass spectrometry identity data, and discuss additional documentation such as specifications, stability information and regulatory support files with the sales team for each project.

How can international buyers get the latest product catalog?

Use the Request a Catalog page or contact the regional desk for the USA and Europe, Russia and CIS, Asia, or the Middle East and East Asia by email, phone or WhatsApp.

Custom Vasopressin CAS NO: 50-57-7 Manufacturer, Manufacturers

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Custom Vasopressin CAS NO: 50-57-7 Manufacturer, Manufacturers

Vasopressin, also known as antidiuretic hormone (ADH) or arginine vasopressin (AVP), is a hormone that plays a crucial role in regulating water and sodium balance in the body. It primarily affects the kidneys, increasing water reabsorption and thus decreasing urine output, and also constricts blood vessels, which can raise blood pressure. Vasopressin is synthesized in the hypothalamus and released from the posterior pituitary gland.

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Product Description

Therapeutic Areas

Human Nervous System: Vasopressin and Cardiovascular Regulation

Vasopressin is a hormone that plays a key role in maintaining osmolality (the concentration of dissolved particles, such as salts and glucose, in the serum) and therefore in maintaining the volume of water in the extracellular fluid (the fluid space that surrounds cells). This is necessary to protect cells from sudden increases or decreases in water content, which are capable of interfering with proper cell function. Normal serum osmolality ranges from about 285 to 300 milliosmoles per kilogram (mOsm/kg) in healthy people. Vasopressin and a hormone called oxytocin evolved from a single primordial neurohypophyseal hormone called vasotocin, which is present in lower vertebrates.

Special nerve cells called osmoreceptors in the hypothalamus are very sensitive to changes in serum osmolality. The osmoreceptors are closely associated with the same nerve cells that produce and secrete vasopressin. Serum osmolality that increases or decreases by as little as 1 percent can cause respective decreases or increases in vasopressin release.

Outlook & Development

This stimulation leads to the separation of vasopressin from molecules of neurophysin, to which vasopressin is loosely attached within the secretory cells. Vasopressin is then released from the posterior pituitary gland, leading to the subsequent retention of water by the kidneys. This inhibition leads to a decrease in vasopressin secretion and a subsequent increase in water excretion. The osmoreceptors are also closely linked to the thirst centre, which is stimulated by high serum osmolality and is inhibited by low serum osmolality in the same way as is vasopressin secretion.

In the kidneys, vasopressin acts on the cells of the collecting ducts. These cells contain receptors for vasopressin that are linked to vesicles that contain special water channels (aquaporins). When the cells are stimulated by vasopressin, the aquaporins fuse with the region of the cell membrane that is exposed to urine, allowing water to enter the cells. The water is then returned to the circulation. This causes the volume of urine to decrease and the urinary content of sodium, chloride, and other substances to increase. When this occurs, the urine is said to be concentrated.

Frequently Asked Questions

What is vasopressin and where is it produced?

Vasopressin, also known as antidiuretic hormone (ADH) or arginine vasopressin (AVP), is synthesized in the hypothalamus and stored/released by the posterior pituitary gland. It regulates water and sodium equilibrium and affects vascular tone.

How does vasopressin control water reabsorption in the kidneys?

It binds to specific receptors on collecting duct cells, prompting vesicles with aquaporin channels to fuse with the cell membrane. This mechanism allows water to re-enter circulation and produces concentrated urine.

What is normal serum osmolality in healthy individuals?

In healthy individuals, normal serum osmolality typically spans from 285 to 300 milliosmoles per kilogram (mOsm/kg).

How sensitive are hypothalamic osmoreceptors to body fluid shifts?

Osmoreceptors can detect variations in serum osmolality of as little as 1 percent, promptly modulating the release of vasopressin to restore balance.

What is the evolutionary origin of vasopressin?

Vasopressin and oxytocin share an evolutionary lineage originating from vasotocin, a primordial neurohypophyseal hormone observed in lower vertebrates.

What is the role of neurophysin in vasopressin secretion?

Within secretory cells, vasopressin is loosely bound to neurophysin molecules; appropriate osmotic stimulation triggers their dissociation before vasopressin enters systemic circulation.